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Pharmacological reversion of sphingomyelin-induced dendritic spine anomalies in a Niemann Pick disease type A mouse model.
EMBO Mol Med. 2014 Mar;6(3):398-413. doi: 10.1002/emmm.201302649. Epub 2014 Jan 21.
EMBO Mol Med. 2014.
PMID: 24448491
Free PMC article.
Carbohydrate metabolism is perturbed in peroxisome-deficient hepatocytes due to mitochondrial dysfunction, AMP-activated protein kinase (AMPK) activation, and peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α) suppression.
Peeters A, Fraisl P, van den Berg S, Ver Loren van Themaat E, Van Kampen A, Rider MH, Takemori H, van Dijk KW, Van Veldhoven PP, Carmeliet P, Baes M.
Peeters A, et al. Among authors: van veldhoven pp.
J Biol Chem. 2011 Dec 9;286(49):42162-42179. doi: 10.1074/jbc.M111.299727. Epub 2011 Oct 14.
J Biol Chem. 2011.
PMID: 22002056
Free PMC article.
The perturbation of carbohydrate metabolism does not require a long term adaptation to the absence of functional peroxisomes as similar metabolic changes were also rapidly induced by acute elimination of Pex5 via adenoviral administration of Cre. ...
The perturbation of carbohydrate metabolism does not require a long term adaptation to the absence of functional peroxisomes as simil …
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Enhanced Ca2+ storage in sphingosine-1-phosphate lyase-deficient fibroblasts.
Claas RF, ter Braak M, Hegen B, Hardel V, Angioni C, Schmidt H, Jakobs KH, Van Veldhoven PP, zu Heringdorf DM.
Claas RF, et al. Among authors: van veldhoven pp.
Cell Signal. 2010 Mar;22(3):476-83. doi: 10.1016/j.cellsig.2009.11.001.
Cell Signal. 2010.
PMID: 19913094
S1P metabolism thus plays a role not only in acute Ca2+ mobilization but also in long-term regulation of Ca2+ homeostasis....
S1P metabolism thus plays a role not only in acute Ca2+ mobilization but also in long-term regulation of Ca2+ homeostasis....
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N-acyl migration in ceramides.
Van Overloop H, Van der Hoeven G, Van Veldhoven PP.
Van Overloop H, et al. Among authors: van veldhoven pp.
J Lipid Res. 2005 Apr;46(4):812-6. doi: 10.1194/jlr.D400034-JLR200. Epub 2005 Jan 16.
J Lipid Res. 2005.
PMID: 15772418
Free article.
Of particular concern is the fact that the O-acylated compounds, which can be considered sphingoid base analogs, can be formed in chloroform or chloroform-methanol mixtures upon storage. For long-term storage, methanol or dichloromethane is the preferred solvent. ...
Of particular concern is the fact that the O-acylated compounds, which can be considered sphingoid base analogs, can be formed in chloroform …
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Maturation of peroxisomes in differentiating human hepatoblastoma cells (HepG2): possible involvement of the peroxisome proliferator-activated receptor alpha (PPAR alpha).
Stier H, Fahimi HD, Van Veldhoven PP, Mannaerts GP, Völkl A, Baumgart E.
Stier H, et al. Among authors: van veldhoven pp.
Differentiation. 1998 Nov;64(1):55-66. doi: 10.1046/j.1432-0436.1998.6410055.x.
Differentiation. 1998.
PMID: 9921653
We have studied the alterations of peroxisomes in the human hepatoblastoma cell line HepG2, induced to differentiate by long-term cultivation (20 days without passaging) using morphological and biochemical techniques as well as mRNA analysis. ...
We have studied the alterations of peroxisomes in the human hepatoblastoma cell line HepG2, induced to differentiate by long-term cul …
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