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Non-electron transfer chain mitochondrial defects differently regulate HIF-1α degradation and transcription.
Shvetsova AN, Mennerich D, Kerätär JM, Hiltunen JK, Kietzmann T. Shvetsova AN, et al. Among authors: hiltunen jk. Redox Biol. 2017 Aug;12:1052-1061. doi: 10.1016/j.redox.2017.05.003. Epub 2017 May 8. Redox Biol. 2017. PMID: 28531964 Free PMC article.
We found that cells lacking the key enzyme 2-enoyl thioester reductase/mitochondrial enoyl-CoA reductase (MECR), and cells lacking manganese superoxide dismutase (MnSOD) showed a reduced induction of HIF-1alpha under long-term (20h) hypoxia. By contrast, cells lacking the …
We found that cells lacking the key enzyme 2-enoyl thioester reductase/mitochondrial enoyl-CoA reductase (MECR), and cells lacking manganese …