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Germline PRDM1 Variant rs2185379 in Long-Term Recurrence-Free Survivors of Advanced Ovarian Cancer.
Mitamura T, Zhai T, Hatanaka KC, Hatanaka Y, Amano T, Wang L, Tanaka S, Watari H. Mitamura T, et al. Among authors: hatanaka y. Pharmgenomics Pers Med. 2022 Nov 29;15:977-984. doi: 10.2147/PGPM.S387120. eCollection 2022. Pharmgenomics Pers Med. 2022. PMID: 36471864 Free PMC article.
PURPOSE: To identify the germline genetic characteristics of long-term recurrence-free survivors that can be applied to establishing a new strategy for curing advanced cancer, we investigated the whole-genome single nucleotide variants of ovarian cancer patients. PATIENTS …
PURPOSE: To identify the germline genetic characteristics of long-term recurrence-free survivors that can be applied to establishing …
Efficient multiple treatments including molecular targeting agents in a case of recurrent hepatocellular carcinoma, post-living donor liver transplantation.
Suzuki R, Goto R, Kawamura N, Watanabe M, Ganchiku Y, Hatanaka KC, Hatanaka Y, Kamiyama T, Shimamura T, Taketomi A. Suzuki R, et al. Among authors: hatanaka y. Clin J Gastroenterol. 2022 Aug;15(4):755-764. doi: 10.1007/s12328-022-01643-3. Epub 2022 May 30. Clin J Gastroenterol. 2022. PMID: 35635645
Here we report that multidisciplinary treatment, including novel molecular targeting therapy with lenvatinib, achieved long-term survival of a patient with post-liver transplantation recurrence of hepatocellular carcinoma. ...
Here we report that multidisciplinary treatment, including novel molecular targeting therapy with lenvatinib, achieved long-term surv …
Subtotal stomach in esophageal reconstruction surgery achieves an anastomotic leakage rate of less than 1%.
Yoshida K, Tanaka Y, Imai T, Sato Y, Hatanaka Y, Suetsugu T, Okumura N, Matsuhashi N, Takahashi T, Yamaguchi K. Yoshida K, et al. Among authors: hatanaka y. Ann Gastroenterol Surg. 2020 May 10;4(4):422-432. doi: 10.1002/ags3.12336. eCollection 2020 Jul. Ann Gastroenterol Surg. 2020. PMID: 32724886 Free PMC article.
We have used SS reconstruction and hand-sutured cervical esophagus-subtotal gastric anastomosis at the neck wound in EC surgery. Short- and long-term outcomes in cases using SS are not well known. METHODS: Between January 2008 and September 2019, 300 patients underwent eso …
We have used SS reconstruction and hand-sutured cervical esophagus-subtotal gastric anastomosis at the neck wound in EC surgery. Short- and …
Comparative genetic analysis of a rare synchronous collision tumor composed of malignant pleural mesothelioma and primary pulmonary adenocarcinoma.
Naka T, Hatanaka Y, Marukawa K, Okada H, Hatanaka KC, Sakakibara-Konishi J, Oizumi S, Hida Y, Kaga K, Mitsuhashi T, Matsuno Y. Naka T, et al. Among authors: hatanaka y. Diagn Pathol. 2016 Apr 18;11:38. doi: 10.1186/s13000-016-0488-0. Diagn Pathol. 2016. PMID: 27091358 Free PMC article.
We experienced a rare synchronous collision tumor composed of malignant pleural mesothelioma (MPM) and primary pulmonary adenocarcinoma (PAC) in a 77-year-old man with a history of long-term smoking and asbestos exposure, and compared the DNA copy number alteration (CNA) a …
We experienced a rare synchronous collision tumor composed of malignant pleural mesothelioma (MPM) and primary pulmonary adenocarcinoma (PAC …
[Risk factors for ischemic heart disease in males in the prime of life: An eight-year follow-up study].
Hatanaka Y, Tamakoshi A, Tsushita K. Hatanaka Y, et al. Sangyo Eiseigaku Zasshi. 2015;57(3):67-76. doi: 10.1539/sangyoeisei.B14008. Epub 2015 Mar 9. Sangyo Eiseigaku Zasshi. 2015. PMID: 25753607 Free article. Japanese.
To prevent ischemic heart disease during the prime of life, offering support for weight control and stopping smoking is necessary in younger age groups. Moreover, implementing a long-term risk management plan to prevent the onset of hypertension, diabetes, or hyperlipidemi …
To prevent ischemic heart disease during the prime of life, offering support for weight control and stopping smoking is necessary in younger …
Direct uptake and degradation of DNA by lysosomes.
Fujiwara Y, Kikuchi H, Aizawa S, Furuta A, Hatanaka Y, Konya C, Uchida K, Wada K, Kabuta T. Fujiwara Y, et al. Among authors: hatanaka y. Autophagy. 2013 Aug;9(8):1167-71. doi: 10.4161/auto.24880. Epub 2013 May 21. Autophagy. 2013. PMID: 23839276 Free PMC article.
In the present study, we show that DNA is also directly taken up by lysosomes and degraded. Like RNautophagy, this autophagic pathway, which we term "DNautophagy," is dependent on ATP. The cytosolic sequence of LAMP2C also directly interacts with DNA, and LAMP2C functions …
In the present study, we show that DNA is also directly taken up by lysosomes and degraded. Like RNautophagy, this autophagic pathway, which …
Discovery of a novel type of autophagy targeting RNA.
Fujiwara Y, Furuta A, Kikuchi H, Aizawa S, Hatanaka Y, Konya C, Uchida K, Yoshimura A, Tamai Y, Wada K, Kabuta T. Fujiwara Y, et al. Among authors: hatanaka y. Autophagy. 2013 Mar;9(3):403-9. doi: 10.4161/auto.23002. Epub 2013 Jan 4. Autophagy. 2013. PMID: 23291500 Free PMC article.
Here, we showed a novel type of autophagy, in which RNA is taken up directly into lysosomes for degradation. This pathway, which we term "RNautophagy," is ATP-dependent, and unlike CMA, is independent of HSPA8/Hsc70. ...
Here, we showed a novel type of autophagy, in which RNA is taken up directly into lysosomes for degradation. This pathway, which we term …
Different characteristic phenotypes according to antibody in myasthenia gravis.
Oh SJ, Morgan MB, Lu L, Hatanaka Y, Hemmi S, Young A, Claussen GC. Oh SJ, et al. Among authors: hatanaka y. J Clin Neuromuscul Dis. 2012 Dec;14(2):57-65. doi: 10.1097/CND.0b013e318275197c. J Clin Neuromuscul Dis. 2012. PMID: 23172384
MuSK Ab+ MG is characterized by younger age at onset, severe and bulbar forms of MG, predominant faciobulbar neck weakness, and a poor response to edrophonium, anticholinesterase, and intravenous immunoglobulin. Long-term outcome showed no difference among 3 types of MG. C …
MuSK Ab+ MG is characterized by younger age at onset, severe and bulbar forms of MG, predominant faciobulbar neck weakness, and a poor respo …
Modulation of synaptic plasticity in the hippocampus by hippocampus-derived estrogen and androgen.
Ooishi Y, Kawato S, Hojo Y, Hatanaka Y, Higo S, Murakami G, Komatsuzaki Y, Ogiue-Ikeda M, Kimoto T, Mukai H. Ooishi Y, et al. Among authors: hatanaka y. J Steroid Biochem Mol Biol. 2012 Aug;131(1-2):37-51. doi: 10.1016/j.jsbmb.2011.10.004. Epub 2011 Oct 31. J Steroid Biochem Mol Biol. 2012. PMID: 22075082 Review.
Rapid actions (1-2h) of 17beta-estradiol (17beta-E2) occur via synapse-localized receptors (ERalpha or ERbeta), while slow genomic E2 actions (6-48h) occur via classical nuclear receptors (ERalpha or ERbeta). The long-term potentiation (LTP), induced by strong tetanus or t …
Rapid actions (1-2h) of 17beta-estradiol (17beta-E2) occur via synapse-localized receptors (ERalpha or ERbeta), while slow genomic E2 action …
Regulation of synaptic plasticity by hippocampus synthesized estradiol.
Barron AM, Hojo Y, Mukai H, Higo S, Ooishi Y, Hatanaka Y, Ogiue-Ikeda M, Murakami G, Kimoto T, Kawato S. Barron AM, et al. Among authors: hatanaka y. Horm Mol Biol Clin Investig. 2011 Feb 1;7(2):361-75. doi: 10.1515/HMBCI.2011.118. Horm Mol Biol Clin Investig. 2011. PMID: 25961274
Locally synthesized estradiol rapidly and potently modulates synaptic plasticity within the hippocampus. E2 rapidly potentiates long-term depression and induces spinogenesis through synaptic estrogen receptors and kinases. The rapid effects of estradiol are followed by slo …
Locally synthesized estradiol rapidly and potently modulates synaptic plasticity within the hippocampus. E2 rapidly potentiates long-term …
22 results